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KMID : 0365220120490020078
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Korean Journal of Public Health
2012 Volume.49 No. 2 p.78 ~ p.87
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Recent trend of ecotoxicological research on combined exposure to pharmaceutical residues in water environment
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Lee Go-Woon
Lee Sae-Ram
Ji Kyung-Hee
Kim Pil-Je
Choi Kyung-Ho
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Abstract
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A number of pharmaceuticals have been detected in the ambient water worldwide. One of the potential public health concerns relating to pharmaceuticals in water is the ecotoxicological consequences of the combined exposure. Due to the physiologically active nature, pharmaceuticals may influence the toxicity of other pharmaceuticals or different groups of water contaminants through various modes of interaction. In this review, major approaches that have been used to estimate the toxicity of mixtures, e.g., dose addition and response addition, are introduced. In addition, published works related to mixture exposure studies of pharmaceuticals were identified and reviewed to understand the current status of knowledge and research trend on this issue. Most studies are focused on multiple pharmaceuticals that were detected in high frequencies and concentrations. Several but limited number of studies were conducted to test the hypotheses that are based on pharmacological functions of given chemicals. Suggestions for future research direction on mixture pharmaceuticals study were made.
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KEYWORD
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Pharmaceuticals, mixture, toxicity, ecotoxicity
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